新加坡六合彩开奖直播 the author:听 is University Research Professor at 新加坡六合彩开奖直播.
It鈥檚 been just over a year since the . Since then, to the chagrin of some and the relief of others, there have been no more such announcements. This is due, in no small part, to discreet actions taken by the People鈥檚 Republic of China, the World Health Organization (WHO) and the Russian Federation.
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The first CRISPR babies
In late November 2018, He Jiankui, a Chinese biophysicist, confirmed he鈥檇 created genetically modified twins in an effort to provide the children with resistance to HIV. A few days later, he presented some of his work at the . At this meeting, He mentioned another ongoing pregnancy involving the use of a genetically modified embryo. To this day, we .
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What we do know is that and shortly thereafter, China鈥檚 National Health Commission drafted new regulations on the clinical use of emerging biomedical technologies, including human genome editing. The final text of the is not yet available and it is not known when these regulations will come into effect.
Based on the draft text open to public comment, research of the type conducted by He would require approval from China鈥檚 highest administrative authority.
Ethics and global governance
In the wake of He鈥檚 controversial experiment, the WHO convened a multi-disciplinary to 鈥渆xamine the scientific, ethical, social and legal challenges associated with human genome editing (both somatic and germ cell).鈥�
Specifically, the committee was tasked by the director general, Tedros Adhanom Ghebreyesus, to advise and make recommendations on appropriate governance mechanisms. The committee (of which I am a member) met for the first time in March 2019.
In June 2019, Russian molecular biologist Denis Rebrikov announced his plans to . Rebrikov would genetically modify early-stage human embryos in his lab and use those embryos to initiate a pregnancy that hopefully would result in the birth of healthy HIV-resistant offspring. Unlike He, however, Rebrikov planned to involve HIV-infected women in his research in an effort to address the risk of transmission of the virus in utero from the pregnant woman to her fetus. ()
In response, on advice from the WHO Expert Advisory Committee, the calling on regulatory and ethics authorities in all countries to refrain from approving research on heritable human genome editing until its ethical and social implications had been properly considered.
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Editing for deafness
Undeterred by the WHO announcement, in and 2019 Rebrikov, confirmed his intention to apply for permission to proceed with heritable human genome editing, but with a different focus. Though it was initially reported that Rebrikov felt 鈥�,鈥� he was unable to find HIV-positive women who did not respond to standard anti-HIV drugs and who wanted to get pregnant to participate in his research.
So, instead of modifying the CCR5 gene which would provide future offspring with resistance to HIV, Rebrikov planned to modify the GJB2 gene to correct a mutation that causes a type of hereditary deafness. According to Rebrikov, there were several couples interested in participating in this research.
Meanwhile, the Russian government issued a statement making it clear that .
In October 2019, the Ministry of Health of the Russian Federation affirmed that the use of heritable genome editing was 鈥減remature.鈥� Further, the ministry officially endorsed the WHO position that it would be irresponsible and unacceptable to use genome-edited embryos to initiate human pregnancies.
Finally 鈥� and most importantly 鈥� .鈥�
This strong statement by the Ministry of Health of the Russian Federation is reassuring. It sets an important example for regulatory authorities around the world who support the to develop 鈥渆ffective governance instruments to deter and prevent irresponsible and unacceptable uses of genome editing of embryos to initiate human pregnancies.鈥�
One year later
In the last lines of my new book I write:
鈥淎s a direct consequence of increasingly audacious moves by some scientists to engineer future generations, important decisions must now be made 鈥攄ecisions that will set a new course for science, society, and humanity. May these decisions be inclusive and consensual. May they be characterized by wisdom and benevolence. And, may we never lose sight of our responsibilities to 鈥榰s all.鈥欌��
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Collectively, all of us (experts and non-experts) have a responsibility to make the best use of emerging technologies to improve the health and well-being of all people everywhere. This can only be achieved through collaborative effort on a global scale.
We need time to carefully consider the kind of world we want to live in and how human genome editing technology might or might not help us build that world. We can鈥檛 do this work properly if scientists brashly go about the business of making genome-edited babies.
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