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Author is a professor and Canada Research Chair in Bioethics and Philosophy at 新加坡六合彩开奖直播.
For several years, scientists have experimented on human embryos with a powerful genome editing tool called CRISPR to see if they could correct genetic errors or reduce the risk of disease. In September, in London and her colleagues reported they had 鈥� to better understand human development.
The use of CRISPR (pronounced 鈥渃risper鈥�) to modify human embryos has prompted a healthy debate on the ethics of human genetic technologies. This tool is controversial, in part, because changes that are made to the embryo could be passed down to future generations. Niakan鈥檚 recent research is novel, and less ethically fraught than some other genome-editing research.
Research labs around the world are using CRISPR to selectively insert, delete or replace DNA with far greater precision and at a lower cost than other genome-editing techniques. Since 2015, five reports have detailed its use in human embryos to correct disease-causing mutations or create resistance to infectious disease.
Scientists have (an inherited blood disorder), (a reaction to eating fava beans), and a . Another experiment used CRISPR to introduce a mutation into a protein called CCR5 in an effort to .
A striking difference
The project led by Niakan had a starkly different aim. It used CRISPR to peek at the earliest stages of human embryonic development by targeting a gene called OCT4, which is active in the cells that go on to form the embryo.
Niakan鈥檚 immediate objective was to better understand the early aspects of human development. But her research eventually may help reveal why some pregnancies end in miscarriages and may improve the success of in vitro fertilization.
Much of the global discussion over the ethics of modifying human embryos has focused on whether the technique might be unsafe or used for non-medical purposes. Niakan鈥檚 recent project brings other aspects of this debate to light. How do scientists acquire the embryos they use in their research, and how are their projects approved?
So far, these types of experiments have been done in China, the United Kingdom and the United States. With only limited data available on the experiments conducted in China, it makes sense to focus the discussion on the experiments based in the United States and in the United Kingdom.
Who鈥檚 taking the risk - and why?
Earlier this year, , a reproductive biologist at Oregon Health and Science University (OHSU), and his colleagues used CRISPR in human embryos to repair a mutation that causes heart disease. From an ethics standpoint, Mitalipov鈥檚 research is more controversial than Niakan鈥檚. The goal of his experiments was to make changes to the human embryo that could be passed on to future generations. Niakan鈥檚 research, on the other hand, aimed to develop our understanding of human embryology.
To do the experiments, Mitalipov鈥檚 team had to create human embryos from donated eggs and sperm. In contrast, Niakan鈥檚 project used embryos that were left over from fertility treatments. This is an important difference.
For Mitalipov鈥檚 study, the women who donated their eggs for research were exposed to the risks associated with hormonal stimulation and egg retrieval. These risks include abdominal pain, vomiting, rapid weight gain, shortness of breath, and damage to the organs that are close to the ovaries. A particularly serious risk is ovarian hyperstimulation syndrome that can require hospitalization.
With Niakan鈥檚 study, women assumed these risks in connection with their IVF treatment, not their participation in research. These women weighed the potential harms of hormonal stimulation and egg retrieval against the potential benefits of having a child using assisted human reproduction. Embryos remaining after fertility treatment were donated to research.
Looking ahead
It鈥檚 also worth examining how these studies were approved. Several committees, panels and review boards from OHSU provided input and guidance prior to granting Mitalipov permission to do his experiments. OHSU is Mitalipov鈥檚 home institution. This raises the spectre of institutional conflict of interest because OHSU stands to benefit from Mitalipov鈥檚 research if his work attracts more research funding or enhances the university鈥檚 reputation.
In the United Kingdom, the governance and oversight of human embryo research lies in the hands of authorities that are legally regulated and are at arms length to the institutions conducting the research. Ethics review of human embryo research occurs at both the national and regional level. The Human Fertilisation and Embryology Authority and the regional research ethics committee before she could begin her experiments.
As genome editing of human embryos becomes more widespread, it is important to understand the differences between one project and the next so that we can meaningfully discuss the range of ethical, social, political and regulatory issues associated with the research.
Read the聽聽at The Conversation Canada. You can also read Dr. Baylis and the University of Saskatchewan's Alana Cattapan .
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