When evolutionary biologist W. Ford Doolittle was working through a few ideas for a recent series of papers, he found inspiration in an unlikely place: an old rock song from his youth.
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It wasn鈥檛 the reverb-laden jangle of the 1965 Rolling Stones tune that spurred him on in his work, but its title. By simply rearranging a few words, he inverted the name鈥檚 meaning and came up with a compelling analogy he could use to support a theory he鈥檇 been working on.
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鈥淚鈥檓 calling this the 鈥業t鈥檚 the Song, Not the Singer鈥� hypothesis,鈥� he says.
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The argument, laid out in two major journal articles published in the past year, sees Dr. Doolittle turning his attention back to some of the bigger philosophical debates in contemporary evolutionary biology 鈥� something he has done to great effect throughout his career. This particular debate is about whether evolution and natural selection can be understood in terms of persistent, community-level metabolic processes, rather than the individual ephemeral entities (organisms and species) that carry them out.
To many molecular biologists, it鈥檚 a radical idea 鈥� one that goes against much of the conventional wisdom in the field. And that鈥檚 exactly the point.
A prestigious award for a disruptive thinker
Dr. Doolittle鈥檚 45-year career at 新加坡六合彩开奖直播 has been defined by just this sort of disruptive, 鈥渨hat if鈥� approach to science. While a lot of microbiologists do their most important work in front of a microscope, many of Dr. Doolittle鈥檚 biggest contributions to the field have grown out of the deep, often contrarian thinking he鈥檚 done in between visits to the lab.
It鈥檚 an approach that has helped cement his status as one of the world鈥檚 top molecular biologists and a trailblazer working on the frontiers of evolutionary biology. And it鈥檚 also one of the many reasons he鈥檚 receiving .
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The $100,000 award, considered among the top research honours in the country, recognizes individuals who have dedicated their careers to pushing the boundaries of knowledge in the social sciences, humanities, health sciences, engineering, and natural sciences.
It's the second year in a row that the Killam Prize in the Natural Sciences has gone to a 新加坡六合彩开奖直播 researcher: last year, Chemistry's Axel Becke received the honour. Other past Dal recipients of a Killam Prize are Sue Sherwin (Philosophy) and Brian Hall (Biology).
Dr. Doolittle with his Herzberg Medal in 2014.
Dr. Doolittle鈥檚 Killam win comes just a few years after becoming Dal鈥檚 first-ever recipient of the Natural Sciences and Engineering Research Council of Canada鈥檚 $1-million Gerhard Herzberg Canada Gold Medal for Science and Engineering, the organization鈥檚 top research honour. Since then, two other Dal researchers (Dr. Becke and Physics鈥� Jeff Dahn) have also been awarded the Herzberg 鈥� a stellar run of three winners in four years.
Pushing against orthodoxy
Dr. Doolittle began his career as a biochemist about a half a century ago when the field of molecular genetics was still fairly young. Many scientists were investigating questions such as 鈥淲hat is a gene?鈥� and 鈥淗ow do genes work?鈥� Today, many of those relatively basic questions have been answered, thanks in part to the work of Dr. Doolittle and other molecular scientists like him. But what happened along the way was a series of watershed discoveries with few comparisons in contemporary science.
"The progress in molecular biology in in the last 50 years, in particular as this progress bears on evolution, has been one of the most astounding intellectual developments in the history of our species,鈥� as Dr. Doolittle describes it.
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That may sound rather grandiose, but consider even a few of the convention-busting discoveries Dr. Doolittle himself has been responsible for and it becomes clear that humanity is much closer now to understanding the origins of life on Earth than it has ever been.
One of Dr. Doolittle鈥檚 first major achievements after arriving at Dal in 1971 was in helping prove something called the 鈥渆ndosymbiont hypothesis,鈥� a rather controversial idea at the time that claimed chloroplasts and mitochondria in plant cells both originated from bacteria that were once free living before they were engulfed by a nucleated host cell.
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鈥淭hat鈥檚 when I really became an evolutionary biologist and when I became interested in using molecular approaches to evolution,鈥� he says. 鈥淚 was more interested in evolutionary questions than in some of the more straightforward biochemical problems I might have been expected to pursue.鈥�
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A decade later, Dr. Doolittle riled many fellow molecular geneticists when he claimed that some DNA in cells was essentially 鈥渟elfish鈥� or parasitic, existing only to replicate itself rather than improve the fitness of its host.
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鈥淓verybody wanted to believe, I think, that the extra DNA in cells was there for some kind of future directed purpose; that evolution can somehow plan for the future, which is nonsense,鈥� he says.
Cutting apart the Tree of Life
Dr. Doolittle is perhaps best known for his work questioning Charles Darwin鈥檚 鈥楾ree of Life鈥� picture of evolution. Darwin鈥檚 150-year old theory embraced the idea that all species can be positioned on a single figurative tree and its branches.
But as scientists came to learn more about the behavior of lower-level life forms (such as bacteria, single-celled organisms and archaea) and about genetics 鈥� both little understood in Darwin鈥檚 time 鈥� it became clear that there was a lot of gene-swapping going on between species. The tree began to look a lot more like a web or network instead, argued Dr. Doolittle.
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In 1999, he published a paper in Science arguing that the rarely challenged Tree of Life metaphor failed to explain more than two-thirds of the four billion years of life on Earth. Some scientists were reluctant to let go of this understanding of Darwin鈥檚 theory, but by now the phenomenon of gene swapping among microbes is widely accepted and often used to help explain why some bacteria develop resistance to antibiotics or 鈥渓earn鈥� to metabolize environmental pollutants.
鈥淭ypical of me, I started to think, well, suppose there was a lot of this [gene swapping] going on and more than we ever dared imagine. What would that do to the philosophical structure of the Tree of Life paradigm?鈥�
Turns out, quite a lot. 听
Establishing Canada鈥檚 leadership in evolutionary microbiology
While a scientist by profession, Dr. Doolittle says his success in challenging the scientific community to rethink the inner workings of DNA and the evolution of the genome derives in part from his skills in using rhetoric to build an argument 鈥� something he credits to taking more humanities courses than science ones as an undergraduate at Harvard University.
Dr. Doolittle's father was an art professor at the University of Illinois, and, growing up, he thought he might follow his father's path into the arts. (He later did so, in a sense, completing a BFA in Photography at NSCAD at the age of 72). Even when the younger Doolittle arrived at Harvard, he was still unsure of what he wanted to be: a scientist or an English professor. It took getting accepted into a special seminar program in biochemistry (and rejected from one in English) for him to truly become submerged in the world of science.
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And submerge himself he did, moving on to Stanford University for his PhD where he got to study alongside some of the pioneering figures in molecular biology of the day. Dr. Doolittle proved himself a skilled experimental biochemist in the lab and began to consider where his career might take him.
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When he joined Dal, it was on a Medical Research Council Scholarship that amounted to a five-year salary grant. He was then hired as an assistant professor in the Department of Biochemistry and Molecular Biology in the Faculty of Medicine and quickly ascended the ranks to become a full professor. (Today, he is professor emeritus.)
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"I've never regretted it. I'm really happy I came here and happy that it worked out," he says, noting that he liked being somewhat removed from the competitive atmosphere at the big-name schools where he studied.
Taking stock of the big picture
For all of his reputation as a contrarian, Dr. Doolittle says he has also done a lot of standard molecular biology throughout his career. It's just that he always gravitated toward experiments that would tell him something about evolution.
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Following the success of his work in the 1970s and the early 1980s, the Canadian Institute for Advanced Research (CIAR) approached him about becoming the director of a new Evolutionary Biology program. He held that role from 1986 鈥� 2007, serving as a mentor to dozens of young molecular and evolutionary biologists who have gone on to become stars in the field in their own right.
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Several of them remain at Dal in the (CGEB) group, which was set up in 2007 as a local wing of a new CIAR program (Integrated Microbial Biodiversity) run out of the University of British Columbia by Dr. Doolittle鈥檚 former grad student, Patrick Keeling. 鈥淚 do think Canada is hitting ways above its weight in terms of early cell evolution and, basically, that鈥檚 because of these programs,鈥� he says.
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With more than 300 publications and 25,000 citations, Dr. Doolittle鈥檚 impact in his field is indisputable.
Looking forward, looking back
Now 75, Dr. Doolittle spends most of his time pondering questions at the border between science and philosophy. He stepped away from running a lab five years ago and all of his current post-docs are Philosophy PhDs, not microbiologists.
Yet, somehow he seems more immersed in his field than ever. Seated in his office in Dal鈥檚 Tupper Building, he is surrounded by piles and piles of books and periodicals. But it鈥檚 a framed Photoshop image on the wall of Dr. Doolittle standing arm in arm with Charles Darwin that seems to sum up his career more than anything else.
He says he created the image as a sort of self-deflating joke about his own importance, but also as a show of affection for Darwin, whom he likes to think would share some of the views of modern evolutionists such as himself if he were alive today.
鈥淚t鈥檚 really hard to get your mind around the scope of evolution 鈥� especially the time it took,鈥� he says. 鈥淲henever I feel insufficiently spiritual, I just try to remind myself of what I believe, which is that this all started in some warm little pond with probably some RNA molecules and somehow they learned how to replicate themselves. And not so suddenly, four billion years later, we have Mozart and Einstein and all that stuff.
"It鈥檚 just amazing to think about it.鈥�
Learn more about Dr. Doolittle's work and achievements, and hear from some of his colleagues, by following along on Twitter with the hashtag ""